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What is the difference between a 0.5 mL and a 1 mL insulin syringe?

On U-100, both use the same unit: 1 unit = 0.01 mL. A 0.5 mL syringe holds 50 units and a 1 mL syringe holds 100 units. The 0.5 mL barrel usually marks every unit; the 1 mL barrel often marks every 2 units, so small amounts are easier to read on the smaller barrel.

The math

0.5 mL × 100 = 50 units
1 mL × 100 = 100 units
mL = units ÷ 100 on both
SyringeU-100 capacityTypical line spacing
0.3 mL30 units1 unit
0.5 mL50 units1 unit
1 mL100 units2 units

Math only, not medical advice. This page converts numbers; it does not recommend any compound or amount.

Draw to
10 units
= 0.1 mL · concentration 2.5 mg/mL (2500 mcg/mL) · 20 draws per vial
Concentration = 5 mg ÷ 2 mL = 2.5 mg/mL
Volume = 250 mcg ÷ 2500 mcg/mL = 0.1 mL
Units = 0.1 mL × 100 (U-100) = 10 units
0102030405060708090100

Math only, not medical advice. Verify every number yourself.

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